Angiogenesis and Non Small Cell Lung Cancer
نویسندگان
چکیده
منابع مشابه
Angiogenesis and non-small cell lung cancer.
Lung cancer is the commonest cause of cancer death in the western world. Recent evidence suggests that angiogenesis is related to poor prognosis in many solid tumours including non-small cell lung cancer. Angiogenesis is controlled by a complex interaction between growth and apoptotic factors, proteases and adhesion molecules. The angiogenic process may prove a target for novel therapies such a...
متن کاملAngiogenesis and Non Small Cell Lung Cancer
Non small cell lung cancer (NSCLC) accounts for approximately 80% of all lung cancers. Despite improvements in treatment protocols the survival rate in NSCLC remains poor. An improved understanding of cancer biology has led to the investigation of angiogenesis in NSCLC development and progression by intratumoral microvessel count or expression of angiogenic markers. The prognostic significance ...
متن کاملAngiogenesis and Non Small Cell Lung Cancer
Non small cell lung cancer (NSCLC) accounts for approximately 80% of all lung cancers. Despite improvements in treatment protocols the survival rate in NSCLC remains poor. An improved understanding of cancer biology has led to the investigation of angiogenesis in NSCLC development and progression by intratumoral microvessel count or expression of angiogenic markers. The prognostic significance ...
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The management of NSCLC has undergone a paradigm shift in the last 5 years with the survival advantage demonstrated by the addition of bevacizumab to standard frontline platinum-based doublet specifically, paclitaxel and carboplatin. The increased toxicity observed in patients with squamous histology and in elderly patients treated with angiogenesis-targeting agents has led to even greater scru...
متن کاملStrategies targeting angiogenesis in advanced non-small cell lung cancer
Tumor angiogenesis is a frequent event in the development and progression of non-small cell lung cancer (NSCLC) and has been identified as a promising therapeutic target. The vascular endothelial growth factor (VEGF) family and other angiogenic factors, including fibroblast growth factor and platelet-derived growth factor, promote the growth of newly formed vessels from preexisting vessels and ...
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ژورنال
عنوان ژورنال: Balkan Journal of Medical Genetics
سال: 2008
ISSN: 1311-0160
DOI: 10.2478/v10034-008-0011-3